Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment.

@article{Guo2003PlateletderivedGF,
  title={Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment.},
  author={Ping Guo and Bo Hu and Weisong Gu and Li Xu and De-gui Wang and Hui-Jen Su Huang and Webster K Cavenee and Shi-Yuan Cheng},
  journal={The American journal of pathology},
  year={2003},
  volume={162 4},
  pages={1083-93}
}
Platelet-derived growth factor (PDGF)-B and its receptor (PDGF-R) beta are overexpressed in human gliomas and responsible for recruiting peri-endothelial cells to vessels. To establish the role of PDGF-B in glioma angiogenesis, we overexpressed PDGF-B in U87MG glioma cells. Although PDGF-B stimulated tyrosine phosphorylation of PDGF-Rbeta in U87MG cells, treatment with recombinant PDGF-B or overexpression of PDGF-B in U87MG cells had no effect on their proliferation. However, an increase of… CONTINUE READING

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