Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasia.

@article{Fudge1996PlateletderivedGF,
  title={Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasia.},
  author={K Fudge and David G. Bostwick and Mark E. Stearns},
  journal={The Prostate},
  year={1996},
  volume={29 5},
  pages={
          282-6
        }
}
BACKGROUND The objective of this study was to evaluate the expression of platelet-derived growth factor (PDGF A, PDGF B) and their receptors (PDGF alpha, PDGF beta) in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma. METHODS Peroxidase-antiperoxidase immunoperoxidase labeling was used to detect the extent of antibody labeling in 29 different high grade PIN specimens. RESULTS PDGF A and PDGF alpha were uniformly expressed in glandular epithelial and stromal cells, whereas PDGF B… CONTINUE READING

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