Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF beta-receptor.

@article{Ruusala1998PlateletderivedGF,
  title={Platelet-derived growth factor (PDGF)-induced actin rearrangement is deregulated in cells expressing a mutant Y778F PDGF beta-receptor.},
  author={Aino Ruusala and Christian Sundberg and Annette Arvidsson and Eva Rupp-Thuresson and Carl-Henrik Heldin and Lena Claesson-Welsh},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 1)},
  pages={111-20}
}
Platelet-derived growth factor-stimulated actin rearrangement and edge ruffle formation have previously been shown to be dependent on activation of phosphatidylinositol 3'-kinase, the activity of which also is important for directed migration of cells. This lipid kinase binds to phosphorylated tyrosine residues Y740 and Y751 in the kinase insert of the human platelet-derived growth factor ss-receptor. We examined the role of two other tyrosine residues in the kinase insert of this receptor… CONTINUE READING

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