Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C.

Abstract

We investigated the role of the thrombin-activated platelet in modulating the rate and extent of activated protein C (APC)-catalyzed inactivation of platelet-derived factor Va and factor VaLeiden. Platelet-derived factor Va and factor VaLeiden were inactivated by APC at near identical rates; however, complete inactivation of the cofactors was never achieved… (More)

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@article{Camire1998PlateletderivedFV, title={Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C.}, author={Rodney M. Camire and Michael Kalafatis and Patricia U Simioni and Alessandro Girolami and Paula B. Tracy}, journal={Blood}, year={1998}, volume={91 8}, pages={2818-29} }