Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells.

@article{Takahashi1996PlateletderivedEC,
  title={Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells.},
  author={Yoko Takahashi and Corazon D. Bucana and Wenbiao Liu and Junya Yoneda and Yasuhiko Kitadai and Karen R. Cleary and Lee M. Ellis},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 16},
  pages={1146-51}
}
BACKGROUND Development of new blood vessels is essential for tumor growth and metastasis and depends on the production of angiogenic factors by tumor and/or infiltrating cells. We previously showed that vascular endothelial growth factor (VEGF) expression and vessel count correlate with metastasis in human colon cancer. Although most tumors with high vessel counts express high levels of VEGF, some do not. Recently, platelet-derived endothelial cell growth factor (PD-ECGF), another potent… CONTINUE READING

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