Platelet-derived endothelial cell growth factor gene therapy for limb ischemia.

@article{Yamada2006PlateletderivedEC,
  title={Platelet-derived endothelial cell growth factor gene therapy for limb ischemia.},
  author={Narihisa Yamada and Wei Li and Akio Ihaya and Tetsuya Kimura and Kouichi Morioka and Takahiko Uesaka and Atsushi Takamori and Mitsuteru Handa and Sawaka Tanabe and Kuniyoshi Tanaka},
  journal={Journal of vascular surgery},
  year={2006},
  volume={44 6},
  pages={1322-8}
}
OBJECTIVES Platelet-derived endothelial cell growth factor (PD-ECGF) is identical to thymidine phosphorylase (TP), and it can induce angiogenesis, including arteriogenesis, in chronically ischemic canine myocardium. Because its effect on peripheral arterial disease has not been elucidated, we investigated whether overexpression of PD-ECGF/TP could ameliorate chronic limb ischemia in rabbits. METHODS Left femoral arteries were resected from 24 male rabbits. After 10 days, a plasmid vector… CONTINUE READING
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