Platelet-derived HMGB1 is a critical mediator of thrombosis.

  title={Platelet-derived HMGB1 is a critical mediator of thrombosis.},
  author={Sebastian Vogel and Rebecca Bodenstein and Qiwei Chen and Susanne Feil and Robert Feil and Johannes Rheinlaender and Tilman E. Sch{\"a}ffer and Erwin Bohn and J. Frick and Oliver Borst and Patrick Muenzer and Britta L Walker and Justin E. Markel and G{\'a}bor Cs{\'a}nyi and Patrick J Pagano and Patricia Loughran and M. Elliott Jessup and Simon C. Watkins and Grant C. Bullock and Jason Lee Sperry and Brian S Zuckerbraun and Timothy R Billiar and Michael T Lotze and Meinrad Gawaz and Matthew D Neal},
  journal={The Journal of clinical investigation},
  volume={125 12},
Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular pattern molecule high-mobility group box 1 (HMGB1) is upregulated by activated platelets in multiple inflammatory diseases; however, the contribution of platelet… CONTINUE READING