Platelet-derived CXCL12 (SDF-1α): basic mechanisms and clinical implications.

  title={Platelet-derived CXCL12 (SDF-1α): basic mechanisms and clinical implications.},
  author={Madhumita Chatterjee and Meinrad Gawaz},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={11 11},
Platelets are a major source of CXCL12 (stromal cell-derived factor -1α, SDF-1α) and store CXCL12 as part of their α-granule secretome. Platelet activation enhances surface expression and release of CXCL12. Platelets and megakaryocytes express CXCR4, the major receptor for CXCL12, and interaction of CXCL12 with CXCR4 regulates megakaryopoiesis and the function of circulating platelets. Platelet-derived CXCL12 also modulates paracrine mechanisms such as chemotaxis, adhesion, proliferation and… CONTINUE READING

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