Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

  title={Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy},
  author={Alejandra Sanjuan-Pla and Iain Macaulay and Christina T Jensen and Petter S Woll and Tiago Lu{\'i}s and Adam J Mead and Susan Moore and Cintia Carella and Sahoko Matsuoka and Tiphaine Bouriez Jones and Onima Chowdhury and Laura Stenson and Michael Lutteropp and Joanna C. A. Green and Raffaella Facchini and Hanane Boukarabila and Amit Grover and Adriana Gambardella and Supat Thongjuea and Joana Carrelha and Paul Tarrant and Deborah Atkinson and Sally-Ann Clark and Claus Nerlov and Sten Eirik W Jacobsen},
The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which are required and sufficient for replenishing all human blood cell lineages at millions of cells per second throughout life. Megakaryocytes in the bone marrow are responsible for the continuous production of platelets in the blood, crucial for preventing bleeding—a common and life-threatening side effect of many cancer therapies—and major efforts are focused at identifying the most suitable cellular and… CONTINUE READING
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