Platelet alpha granules contain a growth factor for fibroblasts.

  title={Platelet alpha granules contain a growth factor for fibroblasts.},
  author={David R Kaplan and Felix C. Chao and Charles Dean Stiles and Harry N. Antoniades and Charles D. Scher},
  volume={53 6},
Platelets contain a polypeptide growth factor that stimulates the replication of normal connective tissue cells; this platelet-derived growth factor (PDGF) is released during the clotting process. Human platelets from normal volunteers were disrupted by nitrogen cavitation, and the subcellular organelles were fractionated by ultracentrifugation through a 30%--60% sucrose gradient. Electron microscopy revealed that fraction 7 (density 1.23 g/liter) contained the largest number of alpha granules… CONTINUE READING

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