Platelet aggregometry in the presence of PGE(1) provides a reliable method for cilostazol monitoring.

@article{Satoh2012PlateletAI,
  title={Platelet aggregometry in the presence of PGE(1) provides a reliable method for cilostazol monitoring.},
  author={Kaneo Satoh and Isao Fukasawa and Kazuya Kanemaru and Shigemi Yoda and Yukio Kimura and Osamu Inoue and Masato Ohta and Hiroyuki Kinouchi and Yukio Ozaki},
  journal={Thrombosis research},
  year={2012},
  volume={130 4},
  pages={
          616-21
        }
}

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References

SHOWING 1-10 OF 28 REFERENCES
Evaluation of the antiplatelet effects of cilostazol, a phosphodiesterase 3 inhibitor, by VASP phosphorylation and platelet aggregation.
TLDR
The antiplatelet effects of cilostazol intake could be evaluated by measuring VASP phosphorylation levels and maximal aggregation rates in platelets by ex vivo treatment with a low concentration of PGE(1).
Effect of cilostazol on platelet aggregation and experimental thrombosis.
TLDR
The drug potently prevented death due to pulmonary thrombosis by platelet aggregates in mice in vivo and cilostazol is a promising antithrombotic drug.
Vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay for platelet response to cilostazol
TLDR
A platelet VASP assay can detect the platelet response to cilostazol with high sensitivity and specificity and is demonstrated to be reliable for clinical use.
Antiaggregatory effect of oral cilostazol and recovery of platelet aggregability in patients with cerebrovascular disease.
TLDR
A new antithrombotic drug, cilostazol, was orally administered at 50, 100, 150 and 200 mg daily for four weeks to 24 patients with cerebrovascular diseases including cerebral thrombosis, cerebral embolism, transient ischemic attacks and cerebral arteriosclerosis suggesting the therapeutic value of the drug even by single administration.
Clinical effects of oral cilostazol on suppression of platelet function in patients with cerebrovascular disease.
TLDR
The new antithrombotic drug cilostazol was administered at daily oral doses of 75, 150 and 300 mg for 2 weeks in 15 patients with cerebrovascular disease and can be considered to be a potent and safe antiplatelet-aggregating agent.
Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells.
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary
TLDR
Adjustment of PRP for platelet count does not provide any advantage and therefore the time‐consuming process of Platelet count adjustment is not necessary, whereas late aggregation using ADP 2 μm in non‐adjusted PRP offers the best discrimination between clopidogrel‐treated patients and healthy controls.
Comparison of the inhibitory effects of cilostazol, acetylsalicylic acid and ticlopidine on platelet functions ex vivo. Randomized, double-blind cross-over study.
TLDR
A randomized double-blind cross-over study to determine the inhibitory effects of acetylsalicylic acid, ticlopidine and cilostazol and CS, a new antithrombotic agent on platelet functions ex vivo found that CS and TP significantly inhibited platelet aggregation induced by ADP.
Cilostazol, an Inhibitor of Type 3 Phosphodiesterase, Produces Endothelium-Independent Vasodilation in Pressurized Rabbit Cerebral Penetrating Arterioles
TLDR
The vasodilator action of cilostazol may, in part, contribute to the beneficial effect of preventing lacunar cerebral infarction in patients with functional damage of the endothelium in cerebral penetrating arterioles.
Cilostazol stroke prevention study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction.
  • F. Gotoh, H. Tohgi, Y. Ohashi
  • Medicine
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2000
TLDR
Long-term administration of cilostazol was effective and safe in the secondary prevention of cerebral infarction and a significant relative-risk reduction was shown in the recurrence of cerebralinfarction.
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