Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVII. Inhibition of leucocyte adherence to endothelium by the oligoamine RE 1492C and the NO-donor RE 2047.

@article{Rehse1995PlateletAI,
  title={Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVII. Inhibition of leucocyte adherence to endothelium by the oligoamine RE 1492C and the NO-donor RE 2047.},
  author={Klaus Rehse and T Ciborski and B. Mueller},
  journal={Archiv der Pharmazie},
  year={1995},
  volume={328 2},
  pages={125-6}
}
The oligoamine RE 1492C (N,N',N"-4-phenylbutyl-1,3,5-benzene-trimethanamine-N,N',N"- triethylcarbamate ) inhibited the electrically provoked leucocyte adhesion to the endothelium of rat mesenteric venoles. An oral dose of 60 mg/kg gave a significant inhibition of 65-78%. This is comparable to effects seen after i.v. administration of iloprost or PGE1, respectively. In the same dosage the NO-donor RE 2047 (3-methyl-N-nitroso-sydnone-5-imine) produced an inhibition of 21-27%.