Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation.

  title={Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation.},
  author={Hayato Iwase and Burcin Ekser and H. Harry Zhou and Eefje M Dons and David K C Cooper and Mohamed B Ezzelarab},
  volume={19 4},
INTRODUCTION Platelet activation/aggregation plays a key role in the dysregulation of coagulation and the development of thrombotic microangiopathy in nonhuman primate recipients of pig xenografts. As a preliminary to the study of anti-platelet therapy in vitro and in vivo, the present study aimed to compare platelet aggregation in whole blood from humans, baboons, and cynomolgus monkeys. METHODS Using "Chrono-log" technology (two-sample four-channel Chrono-log Whole Blood Aggregometer), we… CONTINUE READING
5 Citations
53 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 53 references

Effect of low-molecular-weight heparin (Tinzaprin) and unfractionated heparin on platelet aggregation

  • HB Ravn, C Bregengaard, H Vissinger
  • Clin Appl Thromb Hemost
  • 1996
Highly Influential
13 Excerpts

Low molecular weight heparin

  • J Hirsh, MN Levin
  • Blood
  • 1992
Highly Influential
13 Excerpts

Thrombocy - topenia after pig to baboon liver

  • T Bombeli, BR Schwartz, JM Harlan
  • 2011

Similar Papers

Loading similar papers…