Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation.

@article{Iwase2012PlateletAI,
  title={Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation.},
  author={Hayato Iwase and Burcin Ekser and H. Harry Zhou and Eefje M Dons and David K C Cooper and Mohamed B Ezzelarab},
  journal={Xenotransplantation},
  year={2012},
  volume={19 4},
  pages={233-43}
}
INTRODUCTION Platelet activation/aggregation plays a key role in the dysregulation of coagulation and the development of thrombotic microangiopathy in nonhuman primate recipients of pig xenografts. As a preliminary to the study of anti-platelet therapy in vitro and in vivo, the present study aimed to compare platelet aggregation in whole blood from humans, baboons, and cynomolgus monkeys. METHODS Using "Chrono-log" technology (two-sample four-channel Chrono-log Whole Blood Aggregometer), we… CONTINUE READING
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