Platelet adhesion following the administration of tissue-type plasminogen activator and its reversal by vitamin E in rats.

@article{Jen1996PlateletAF,
  title={Platelet adhesion following the administration of tissue-type plasminogen activator and its reversal by vitamin E in rats.},
  author={Chauying Jack Jen and Hiep Phuc Dong and Hsing I. Chen and L C Wing and Michael J. Tang and W C Chang and M. T. Lin and Gui Ying Shi},
  journal={Thrombosis and haemostasis},
  year={1996},
  volume={75 1},
  pages={101-6}
}
Thrombolytic therapy is known to induce platelet-related side effects. We used a parallel-plate flow chamber, which was connected to the femoral artery of the rat, to measure platelet adhesion ex vivo. A collagen-coated arterioarterial shunt between two carotid arteries was used to measure shunt patency duration as an index of antithrombotic efficacy. Tissue-type plasminogen activator (t-PA), vitamin E, and the combination of these two were intravenously administered for 60 min. Measurements… CONTINUE READING

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