Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen.

@article{Roberts1995PlateletAI,
  title={Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen.},
  author={Jessica J. Roberts and Steven E Rodgers and John H Drury and Leonie K. Ashman and John Viner Lloyd},
  journal={British journal of haematology},
  year={1995},
  volume={89 4},
  pages={853-60}
}
MAb 14A2.H1 identifies a novel low-abundance platelet surface antigen, PETA-3, which is a member of the tetra-span (TM4) family. This MAb brings about platelet aggregation and mediator release, which is completely inhibitable by prostaglandin E1, and partially inhibitable by aspirin and ketanserin. Platelet activation by MAb 14A2.H1 is dependent on interaction with both the platelet Fc receptor, Fc gamma RII, and the specific antigen as it was prevented by either a blocking MAb to Fc gamma RII… CONTINUE READING