Platelet activation factor analogs and antagonists

  title={Platelet activation factor analogs and antagonists},
  author={Marina A Sablina and I. P. Ushakova and Galina A Serebrennikova},
  journal={Pharmaceutical Chemistry Journal},
PAF is a powerful mediator of many biological processes: it stimulates platelet and neutrophil degranulation and aggregation, it increases the permeability of blood vessels, and it is a modulator of intracellular signalling [24]. It also plays an important role in a number of physiological and pathological reactions of the body, such as inflammation, anaphylactic shock, allergy, hypotension, ischemic heart disease, etc. [11]. Tissues containing high levels of phospholipids with simple ether… CONTINUE READING