Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome.

@article{Karpman2001PlateletAB,
  title={Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome.},
  author={Diana Karpman and Deppie Papadopoulou and Kenneth Nilsson and Agneta Sj{\"o}gren and C. Mikaelsson and Stephan Lethagen},
  journal={Blood},
  year={2001},
  volume={97 10},
  pages={3100-8}
}
Thrombocytopenia caused by platelet consumption in thrombi is a major manifestation of hemolytic uremic syndrome (HUS) associated with Shiga toxin (Stx) producing Escherichia coli. Platelets have glycosphingolipid receptors capable of binding Stx, but a direct interaction between the toxin and platelets, leading to platelet activation, has not been reported. In this study, it is shown that Stx1 and its B (binding) subunit (Stx1B), at 10 pg/mL to 10 ng/mL, bound to platelets. Toxin was… CONTINUE READING

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teropathogens in adult patients with diarrhea and healthy controls : a one - year prospective study in a Swedish clinic for infectious disease

B Svenungsson, Å Lagergren, E Ekvall
Clin Infect Dis • 2000

Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1

FB JrTaylor, VL Tesh, L DeBault
Am J Pathol • 1999

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