Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia.

@article{Wun1997PlateletAA,
  title={Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia.},
  author={Ted Wun and Teresa G Paglieroni and Fern Tablin and Jeanna Welborn and Karen C Nelson and A Cheung},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={129 5},
  pages={507-16}
}
Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anemia. Platelets may play a role in this vasculopathy. Samples from 12 adults patients with sickle cell anemia were examined for evidence of platelet activation and formation of platelet-erythrocyte aggregates (PEA) using fluorescent-labeled monoclonal antibodies and flow cytometry. We noted an increased expression of activation-dependent antigens on the platelets from patients with sickle cell… CONTINUE READING