Platelet activation and microfilament bundling

@article{Gonnella1981PlateletAA,
  title={Platelet activation and microfilament bundling},
  author={Patricia A. Gonnella and Vivianne T. Nachmias},
  journal={The Journal of Cell Biology},
  year={1981},
  volume={89},
  pages={146 - 151}
}
Human platelets were obtained in the fully resting state by treating discoid populations with 1.5 mM tetracaine and in the activated state by treatment with 2 microM A-23187. After gel filtration or washing, respectively, platelet suspensions were lysed with 1% Triton X-100 at pH 6.8. The precipitates from resting platelets viewed by negative staining appeared predominantly granular with a few very short microfilaments. They contained polypeptides of 250, 100, 45, 38, 36.5, and 35 Kdaltons, and… CONTINUE READING
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