Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration.

@article{Mazereeuw2013PlateletAF,
  title={Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration.},
  author={Graham Mazereeuw and Nathan Herrmann and Steffany A. L. Bennett and Walter Swardfager and Hongbin Xu and Nico Valenzuela and Stephen Fai and Krista L. Lanct{\^o}t},
  journal={Neuroscience and biobehavioral reviews},
  year={2013},
  volume={37 8},
  pages={1611-21}
}
The persistence of a depressive episode in coronary artery disease (CAD) patients not only heightens the risk of acute ischemic events, but it is also associated with accelerated cognitive decline. Antidepressant interventions for depression in CAD have only modest effects and novel approaches are limited by a poor understanding of etiological mechanisms. This review proposes that the platelet activating factor (PAF) family of lipids might be associated with the persistence of a depressive… CONTINUE READING
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