Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures.

@article{Anandi2016PlateletactivatingFP,
  title={Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures.},
  author={V Libi Anandi and K A Ashiq and K Nitheesh and Mayurika Lahiri},
  journal={Oncology reports},
  year={2016},
  volume={35 1},
  pages={179-88}
}
A plethora of studies have demonstrated that chronic inflammatory microenvironment influences the genesis and progression of tumors. Such microenvironments are enriched with various lipid mediators. Platelet activating factor (PAF, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is one such lipid mediator that is secreted by different immune cell types during inflammation and by breast cancer cells upon stimulation with growth factors. Overexpression of PAF-receptor has also been observed in many… CONTINUE READING

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