• Biology, Medicine
  • Published in
    The Journal of biological…
    1991

Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

@article{GomezCambronero1991PlateletactivatingFI,
  title={Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.},
  author={Julian Gomez-Cambronero and Eugenia Wang and Gary M. Johnson and C K Huang and Ramadan I. Sha'afi},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 10},
  pages={
          6240-5
        }
}
The addition of platelet-activating factor (PAF) to human neutrophils increases the levels of the tyrosine phosphorylation in several proteins. These proteins have molecular weights of 41 (pp41), 54 (pp54), 66 (pp66), 104 (pp104), and 116 (pp116) kDa. The effect of PAF was dose-dependent and could be seen at concentrations as low as 1 nM. The nonmetabolizable bioactive PAF analog, C-PAF, caused an increase in the level of phosphorylation of the same proteins in a time- and dose-dependent manner… CONTINUE READING

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Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes.

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