Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

@article{GomezCambronero1991PlateletactivatingFI,
  title={Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.},
  author={J. Gomez-Cambronero and E. Wang and G. Johnson and C. K. Huang and R. Sha'afi},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 10},
  pages={
          6240-5
        }
}
The addition of platelet-activating factor (PAF) to human neutrophils increases the levels of the tyrosine phosphorylation in several proteins. These proteins have molecular weights of 41 (pp41), 54 (pp54), 66 (pp66), 104 (pp104), and 116 (pp116) kDa. The effect of PAF was dose-dependent and could be seen at concentrations as low as 1 nM. The nonmetabolizable bioactive PAF analog, C-PAF, caused an increase in the level of phosphorylation of the same proteins in a time- and dose-dependent manner… Expand
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