Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils.

@article{Swain1998PlateletactivatingFI,
  title={Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils.},
  author={Steve D. Swain and Peggy L. Bunger and Karen M. Sipes and Laura K. Nelson and Kathryn L Jutila and Shane M Boylan and Mark T Quinn},
  journal={Journal of leukocyte biology},
  year={1998},
  volume={64 6},
  pages={817-27}
}
We characterized the dose response of bovine neutrophils to platelet-activating factor (PAF) with respect to the following functions: calcium flux and membrane potential changes, actin polymerization, degranulation, and the production and/or priming of the oxidative burst. PAF at very low concentrations (10(-10) and 10(-9) M) caused changes in intracellular calcium and membrane potential in bovine neutrophils, whereas moderate PAF concentrations (> or = 10(-7) M) resulted in increased actin… CONTINUE READING
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