Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway.

  title={Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway.},
  author={Vladimir V. Kravchenko and Zhengwei Pan and Jiahuai Han and Jean Marc Herbert and Richard J Ulevitch and Richard D Ye},
  journal={The Journal of biological chemistry},
  volume={270 25},
The capability of platelet-activating factor (PAF) to induce transcription factor activation was examined. In stably transfected Chinese hamster ovary cells expressing the PAF receptor (CHO-PAFR), PAF stimulation resulted in the nuclear expression of a DNA binding activity with specificity to the kappa B sequence. The p50 and p65 proteins, constituents of the prototypic nuclear factor kappa B (NF-kappa B), were identified as components of the DNA protein complexes by antipeptide antibodies in… CONTINUE READING


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