Corpus ID: 36818065

Platelet-activating factor antagonists.

  title={Platelet-activating factor antagonists.},
  author={J M Negro Alvarez and J C Miralles L{\'o}pez and J L Ortiz Mart{\'i}nez and A Abell{\'a}n Alem{\'a}n and R Rubio del Barrio},
  journal={Allergologia et immunopathologia},
  volume={25 5},
Platelet-activating factor (PAF), identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, exhibits potent proinflammatory properties. PAF is produced by numerous cell types, including endothelial cells, neutrophils, monocytes, macrophages, basophils, eosinophils and mastocytes. Since the discovery and identification of the chemical structure of PAF, a large variety of specific PAF-receptor antagonists, both natural and synthetic compounds, have been described. Intensive research has… Expand