Platelet-activating factor and progressive brain damage following focal brain injury.

  title={Platelet-activating factor and progressive brain damage following focal brain injury.},
  author={Kai U. Frerichs and Perttu J Lindsberg and John M. Hallenbeck and Giora G Z Feuerstein},
  journal={Journal of neurosurgery},
  volume={73 2},
The effects of a platelet-activating factor (PAF) antagonist on brain edema, cortical microcirculation, blood-brain barrier (BBB) disruption, and neuronal death following focal brain injury are reported. A neodymium:yttrium-aluminum-garnet (Nd:YAG) laser was used to induce highly reproducible focal cortical lesions in anesthetized rats. Secondary brain damage in this model was characterized by progressive cortical hypoperfusion, edema, and BBB disruption in the vicinity of the hemispheroid… CONTINUE READING
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