Platelet-activating factor and Escherichia coli O157:H7 infections


The role of platelet-activating factor (PAF), a phospholipid inflammatory mediator, in Escherichia coli O157:H7-associated hemolytic uremic syndrome (HUS) is unknown. PAF is synthesized by diverse cells and is degraded by PAF-acetylhydrolase (PAF-AH). Deficient PAF-AH activity results from a G→T transversion at position 994 of exon 9. We examined children… (More)
DOI: 10.1007/s00467-002-0970-7


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