Platelet-activating factor acetylhydrolase increases during macrophage differentiation. A novel mechanism that regulates accumulation of platelet-activating factor.

@article{Elstad1989PlateletactivatingFA,
  title={Platelet-activating factor acetylhydrolase increases during macrophage differentiation. A novel mechanism that regulates accumulation of platelet-activating factor.},
  author={Mark R. Elstad and Diana M. Stafforini and Thomas M McIntyre and Stephen M. Prescott and Guy A. Zimmerman},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 15},
  pages={8467-70}
}
Monocytes and macrophages produce bioactive lipids, such as platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, PAF), that mediate inflammation. These cells synthesize PAF following their activation, but not constitutively. Previous studies have demonstrated that PAF accumulation is regulated by the activity of the synthetic enzymes. We observed that the accumulation of PAF in stimulated human monocytes decreased by 90% as they differentiated into macrophages. There was… CONTINUE READING

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