Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.

Abstract

1. To investigate the role of platelet activating factor (PAF) in the immediate asthmatic response, we examined the bronchial reactivity to histamine after administration of PAF to guinea-pigs or antigen challenge to passively sensitized guinea-pigs. 2. A bolus injection of PAF (20-40 ng kg-1), which did not cause a significant increase in intrathoracic… (More)

Topics

Cite this paper

@article{Morooka1992PlateletactivatingF, title={Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.}, author={Satoshi Morooka and M. Uchida and Naoki Imanishi}, journal={British journal of pharmacology}, year={1992}, volume={105 3}, pages={756-62} }