Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.

  title={Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.},
  author={Satoshi Ishii and Takao Shimizu},
  journal={Progress in lipid research},
  volume={39 1},
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was initially recognized for its potential to induce platelet aggregation and secretion, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues, many of which also produce the molecule. PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. PAF receptor is linked to… CONTINUE READING
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