Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells.

@article{Ma2004PlateletactivatingF,
  title={Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells.},
  author={Xiang Ma and Paulo Ottino and Haydee E P Bazan and Nicolas G Bazan},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 9},
  pages={2915-21}
}
PURPOSE Platelet-activating factor (PAF) is a potent proinflammatory mediator that accumulates in the cornea after injury and induces the expression of genes related to inflammation and wound healing. The current study was conducted to investigate the direct effect of PAF on corneal neovascularization and on the expression of angiogenic growth factors in vascular endothelial cells. METHODS Pellets containing carbamyl-PAF (cPAF) were implanted in corneas of wild-type or PAF-receptor (PAF-R… CONTINUE READING

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