Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs.

@article{Armstead1988PlateletAF,
  title={Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs.},
  author={William M Armstead and Massroor Pourcyrous and Robert Mirro and Charles W. Leffler and David William Busija},
  journal={Circulation research},
  year={1988},
  volume={62 1},
  pages={
          1-7
        }
}
This study characterized the nature of the response to platelet activating factor (PAF) in the cerebral microcirculation of the newborn pig. Pial arterioles were observed directly using a closed cranial window in chloralose-anesthetized piglets. Topical application of 10-100 ng/ml PAF produced dose-dependent decreases in pial arteriolar diameter; diameters were 193 +/- 27 microns for control, 167 +/- 25 microns at 10 ng/ml, and 129 +/- 21 microns at 100 ng/ml. Topical application of 30-300 ng… CONTINUE READING

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BusijaDW, LefflerCW, DG Beasley
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