Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils

@article{Benveniste1974PlateletactivatingFA,
  title={Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils},
  author={Jacques E. Benveniste},
  journal={Nature},
  year={1974},
  volume={249},
  pages={581-582}
}
AN increase in vascular permeability as a result of the release of vasoactive amines has been implicated as a ‘trigger mechanism’ of immune complex deposition1,2. Several immunological mechanisms of vasoactive amine release from rabbit platelets have been described3. Experiments have correlated the presence of one of these mechanisms, a complement-independent, leukocyte-dependent reaction, with the vascular deposition of complexes in acute4 and chronic5 serum sickness of rabbits. We have… Expand
Platelet-Activating Factor: A Secretory Product from Phagocytes
Platelet-activating factor was initially described by Benveniste, Henson, and Cochrane in their 1972 report as a substance released from IgE-stimulated basophils that could trigger the secretoryExpand
Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis.
TLDR
Platelet-activating factor has been implicated as a mediator in both allergic and nonallergic inflammatory diseases, including allergic rhinitis, sepsis, atherosclerotic disease, and malignancy, in which PAF signaling has an established role. Expand
Platelet activating factor in allergies
TLDR
The PAF increases the permeability of skin’s capillaries and indices the development of wheals, flare, and inflammatory reactions in the skin, and pathophysiological mechanism of the PAF in anaphylaxis bronchial asthma and urticaria was discussed. Expand
Structural analysis of purified platelet-activating factor by lipases
TLDR
Results of these experiments suggest that PAF is a 1-lyso-glycerophospholipid, a newly described mediator of anaphylaxis which has been implicated in the deposition of immune complexes in acute serum sickness in rabbits. Expand
The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes.
TLDR
The purpose of the present report was to comparatively study the mechanism of PAF release from PMN and monocytes under phagocytic stimuli. Expand
Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion.
  • P. Henson
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1977
TLDR
It was concluded that the same stimulus-specific activable protease (esterase) was most likely involved in PAF-induced aggregation and secretion and that the two platelet responses can be independent of aggregation. Expand
Pafacether (Platelet-activating Factor)
TLDR
The variety of the sources and targets of this mediator makes it a candidate as an instrumental agent in various lung diseases such as asthma and acute res­ piratory distress syndrome. Expand
Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF).
TLDR
The presence of a similar acid-labile factor in normal human serum (H-ALF) may be of great importance during inflammation because it so rapidly degrades PAF in a manner analogous to the control of other potent mediators of inflammation such as histamine, slow-reacting substance of anaphylaxis (SRS-A), and eosinophil chemotactic factors (ECF-A). Expand
Aggregation of equine platelets by PAF (platelet-activating factor)
TLDR
The platelet arachidonate pathway appeared to play no role in PAF-induced aggregation as exogenous archidonate did not enhance the reaction, nor were equine platelets pretreated with 38 μM aspirin inhibited in their response to PAF. Expand
Activation of Platelets by Platelet Activating Factor (PAF) Derived from IgE‐Sensitized Basophils
TLDR
PAF is a unique stimulus for platelets and that secretion and aggregation are not necessarily accompanied by PF3 generation, but other stimuli also initiated both secretion and PF3 activation. Expand
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References

SHOWING 1-7 OF 7 REFERENCES
LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS THE ROLE OF IGE, BASOPHILS, AND A PLATELET-ACTIVATING FACTOR
We have studied the leukocyte-dependent mechanism of histamine release (LDHR) from rabbit platelets, a complement-independent mechanism which has been implicated in the deposition of immune complexesExpand
AN EOSINOPHIL LEUKOCYTE CHEMOTACTIC FACTOR OF ANAPHYLAXIS
TLDR
ECF-A represents a hitherto undescribed agent which selectively attracts eosinophil leukocytes and is distinguishable from a previously described complement-dependent eOSinophilotactic factor ( ECF-C). Expand
ACUTE IMMUNE COMPLEX DISEASE IN RABBITS
By depletion of C3 from rabbits undergoing acute experimental immune complex disease with an anticomplementary factor in cobra venom, it has been possible to demonstrate that deposition of theExpand
STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS
  • C. Cochrane
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1963
Localization of circulating antigen-antibody complexes in vessels of guinea pigs by means of anaphylactic shock was found to be mediated by histamine that was released at the time of anaphylaxis. TheExpand
Slow reacting substance of anaphylaxis.
Publisher Summary This chapter describes the biological implications of slow reacting substance for the entire subject of acute immunologic reactions and their pharmacologic manipulations and alsoExpand