Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.

@article{Koupenova2014PlateletTLR7MH,
  title={Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.},
  author={Milka Koupenova and Olga I. Vitseva and Christopher R. MacKay and Lea M. Beaulieu and Emelia J Benjamin and Eric O. Mick and Evelyn A Kurt-Jones and Katya Ravid and Jonathan E. Freedman},
  journal={Blood},
  year={2014},
  volume={124 5},
  pages={
          791-802
        }
}
Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection with encephalomyocarditis virus (EMCV) rapidly reduces platelet count, and this response is attributed to platelet Toll-like receptor 7 (TLR7). Platelet-TLR7 stimulation mediates formation of large platelet-neutrophil aggregates, both in mouse and human blood. Intriguingly, this process results in internalization of platelet CD41-fragments… CONTINUE READING

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