Platelet-Stored Angiogenesis Factors: Clinical Monitoring Is Prone to Artifacts

@inproceedings{Starlinger2011PlateletStoredAF,
  title={Platelet-Stored Angiogenesis Factors: Clinical Monitoring Is Prone to Artifacts},
  author={P Starlinger and Lejla Alidzanovic and Dominic Schauer and Philipp Brugger and Silvia Sommerfeldt and Irene Kuehrer and Sebastian F Schoppmann and Michael Gnant and Christine Brostjan},
  booktitle={Disease markers},
  year={2011}
}
BACKGROUND The analysis of angiogenesis factors in the blood of tumor patients has given diverse results on their prognostic or predictive value. Since mediators of angiogenesis are stored in platelets, their measurement in plasma is sensitive to inadvertent platelet activation during blood processing. METHODS Variants of blood withdrawal and plasma preparation were evaluated by ELISA for the detection of TSP-1, PF-4, VEGF and PD-ECGF. A total of 22 pancreatic cancer patients and 29 healthy… CONTINUE READING

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