Platelet-Rich Plasma

@article{Foster2009PlateletRichP,
  title={Platelet-Rich Plasma},
  author={Timothy E. Foster and Brian L. Puskas and Bert R. Mandelbaum and Michael B. Gerhardt and Scott A. Rodeo},
  journal={The American Journal of Sports Medicine},
  year={2009},
  volume={37},
  pages={2259 - 2272}
}
Platelet-rich plasma (PRP) has been utilized in surgery for 2 decades; there has been a recent interest in the use of PRP for the treatment of sports-related injuries. PRP contains growth factors and bioactive proteins that influence the healing of tendon, ligament, muscle, and bone. This article examines the basic science of PRP, and it describes the current clinical applications in sports medicine. This study reviews and evaluates the human studies that have been published in the orthopaedic… 

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What Is Platelet-Rich Plasma?
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Tutto sul PRP
TLDR
Deep studies to better understand which biological variables could influence the clinical outcome are needed, together with further high-level research to determine the best indication criteria and application methods of PRP.
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References

SHOWING 1-10 OF 116 REFERENCES
The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment.
The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
TLDR
The aim of this literature review was to describe the bioactivities ofPRP, elucidate the different techniques for PRP preparation, to review animal and human studies, and to evaluate the evidence regarding the use of PRP in trauma and orthopaedic surgery to clarify risks and to provide guidance for future research.
Platelet-rich plasma (PRP): what is PRP and what is not PRP?
  • R. Marx
  • Biology, Medicine
    Implant dentistry
  • 2001
TLDR
The definition of PRP, its safety, its proper development, and its most efficacious means of application are discussed.
Platelet rich plasma injection grafts for musculoskeletal injuries: a review
TLDR
This article introduces the reader to PRP therapy and reviews the current literature on this emerging treatment modality, which provides a promising alternative to surgery by promoting safe and natural healing.
Platelet Rich Concentrate: Basic Science and Current Clinical Applications
Improvements in resuscitation, dissemination of ATLS protocols, and growth of regional and local trauma centers has increased the survivability after severe traumatic injuries. Furthermore, advances
Platelet-Rich Plasma and Bone Graft Materials: A Review and a Standardized Research Protocol
TLDR
A standardized research protocol for the use of, and evaluation of PRP and bone grafts is suggested.
Can Platelet-Rich Plasma Enhance Tendon Repair?
TLDR
In human tenocyte cultures, PRCR, but also PPCR, stimulates cell proliferation and total collagen production and slightly increases the expression of matrix-degrading enzymes and endogenous growth factors.
Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery
TLDR
The authors describe platelet biology and its role in wound healing; the preparation, characterization, and use of platelet-rich plasma; and those applications in plastic surgery for which it may be useful.
Histological evaluation of sinus augmentation using platelet rich plasma (PRP): a case series.
TLDR
The findings suggest that the addition of PRP to bone derivative/substitute materials may not significantly enhance bone formation in the maxillary sinus area.
Histological evaluation of sinus augmentation using platelet rich plasma (PRP): a case series.
TLDR
The findings suggest that the addition of PRP to bone derivative/substitute materials may not significantly enhance bone formation in the maxillary sinus area.
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