Platelet-Rich Plasma: A Promising Product for Treatment of Peripheral Nerve Regeneration After Nerve Injury

@article{Yu2011PlateletRichPA,
  title={Platelet-Rich Plasma: A Promising Product for Treatment of Peripheral Nerve Regeneration After Nerve Injury},
  author={Wen Jun Yu and Jian Wang and Jun Yin},
  journal={International Journal of Neuroscience},
  year={2011},
  volume={121},
  pages={176 - 180}
}
  • W. Yu, Jian Wang, Jun Yin
  • Published 18 February 2011
  • Biology, Medicine
  • International Journal of Neuroscience
ABSTRACT Nerve regeneration includes regrowth of injured axons as well as myelination, restoration of synaptic connections and recovery of physiological functions. Platelet-rich plasma (PRP) is prepared from the patient's own blood and contains growth factors that influence wound healing and used in various surgical fields including oral and maxillofacial surgery. When platelets are activated either ex vivo or in vivo, growth factors and proteins were released from platelets' alpha granules… 
Platelet-Rich Plasma for Injured Peripheral Nerves: Biological Repair Process and Clinical Application Guidelines
TLDR
In vitro and in vivo studies showed the neuroprotective, neurogenic and neuroinflammatory modulator effect of PRP, and it has been demonstrated clinically that PRP infiltrations improve clinical symptoms and enhance the sensory and motor functional nerve muscle unit recovery.
Platelet‐Rich Fibrin Conduits as an Alternative to Nerve Autografts for Peripheral Nerve Repair
TLDR
Autologous nerve GRAFT and PRF‐filled autogenous vein conduits were associated with similar outcomes, and worse than those observed in SHAM controls, suggesting vein conduit filled with PRF may be a favorable alternative treatment to nerve grafts.
Effect of platelet‐rich plasma on reconstruction with nerve autografts
The role of platelet-rich plasma in tissue regeneration
TLDR
The current literature on the use of PRP is summarized, areas of controversy and emerging clinical applications are highlighted and results from clinical studies have been encouraging, and PRP administration remains an attractive strategy given its cost-effective and minimally invasive nature.
Effects of platelet-rich plasma on nerve regeneration in a rat model.
TLDR
Positive effects of platelet-rich plasma on nerve regeneration were demonstrated in rats, and motor recovery was significantly better in the Platelet-Rich plasma group than the control group.
The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair.
TLDR
This current report summarizes some of the more recent studies in the use of PRP as it relates to muscle healing, in both the in vitro and clinical arenas.
The Effect of Subepineural Platelet-rich Plasma on Regeneration of the Sciatic Nerve in a Rat Model
TLDR
It seems that PRP may have an important role in peripheral nerve regeneration and functional recovery after nerve laceration and repair and further clinical evaluation is recommended.
Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction
TLDR
It is concluded that the preponderance of evidence suggests that PRP has the capacity to induce all the claimed influences, although this position cannot be definitively argued.
Platelet-Rich Plasma in Regenerative Medicine
TLDR
In this chapter, the current literature on the use of PRP in regenerative medicine is reviewed highlighting both some of the controversy surrounding this approach and some emerging clinical applications.
An autologously generated platelet-rich plasma suturable membrane may enhance peripheral nerve regeneration after neurorraphy in an acute injury model of sciatic nerve neurotmesis.
TLDR
The data show that the application of a PRP fibrin membrane around the neurorraphy improves the nerve regeneration process in a rat sciatic nerve model and could perform an action not only as a source of bioactive proteins but also as a nerve guide to hold the scar reaction and thus improve axonal regeneration.
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References

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TLDR
In this animal model, the application of PRP to the repair site helped to improve remyelinization of the sciatic nerve in rats when the epineural repair was done with six sutures.
The biology of platelet-rich plasma and its application in oral surgery: literature review.
TLDR
The aim of this literature review is to evaluate the scientific evidence regarding the use of PRP in dentistry, to describe the different bioactive substances included in PRP and their participation in the healing process, to elucidate the different techniques and available technology for PRP preparation, and to clarify risks.
Platelet-Rich Plasma: Support for Its Use in Wound Healing
TLDR
A review of the literature shows few studies performed with scientific rigor, although the safety of PRP appears to be validated, and additional studies may establish PRP as an efficacious treatment modality and guide future treatment of chronic diabetic foot ulceration.
The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model.
TLDR
Results show that the application of PRP to the site of CN-crush injury facilitates nerve regeneration and recovery of erectile function and indicates that clinical application ofPRP has potential repairing effect on CN and peripheral nerves.
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TLDR
It is found that in vitro incubation of chronically denervated SCs with transforming growth factor‐β re‐established their growth‐supportive phenotype in vivo, consistent with the idea that the interaction between invading macrophages and denervate SCs during Wallerian degeneration is essential to sustain axonal regeneration by promoting the growth-supportive SC phenotype.
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TLDR
The functional, electrophysiological and histological examinations demonstrate the treatment with rhbFGF/ACS can enhance rat sciatic nerve repair, and its effectiveness is better than free rhBFGF alone.
Platelet gel does not improve peripheral nerve regeneration: An electrophysiological, stereological, and electron microscopic study
TLDR
The results suggest that PG does not improve axon regeneration after microsurgical reconstruction of a nerve gap by collagen tubes, and it was expected that regeneration degree of the nerve fibers of CT+PG group would be better than CT group, but this was not the case.
Effect of neural‐induced mesenchymal stem cells and platelet‐rich plasma on facial nerve regeneration in an acute nerve injury model
The purpose of this study was to investigate the effects of platelet‐rich plasma (PRP) and neural‐induced human mesenchymal stem cells (nMSCs) on axonal regeneration from a facial nerve axotomy
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