Platelet Protein Kinase C-Deficiency With Human RUNX 1 Mutation PRKCQ Is a Transcriptional Target of RUNX 1

@inproceedings{Jalagadugula2011PlateletPK,
  title={Platelet Protein Kinase C-Deficiency With Human RUNX 1 Mutation PRKCQ Is a Transcriptional Target of RUNX 1},
  author={Gauthami S. Jalagadugula and Guangfen Mao and Gurpreet Kaur and Danny Natarajan Dhanasekaran and A Koneti Rao},
  year={2011}
}
Objective—Mutations in the hematopoietic transcription factor RUNX1 cause thrombocytopenia and impaired platelet function. In a patient with a heterozygous mutation in RUNX1, we have described decreased platelet pleckstrin phosphorylation and protein kinase C(PKC, gene PRKCQ) associated with thrombocytopenia, impaired platelet aggregation, and dense granule secretion. Little is known regarding regulation of PKCin megakaryocytes and platelets. We have addressed the hypothesis that PRKCQ is a… CONTINUE READING
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