Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules

@article{Diacovo1996PlateletMediatedLD,
  title={Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules},
  author={T. Diacovo and K. Puri and R. A. Warnock and T. Springer and U. V. von Andrian},
  journal={Science},
  year={1996},
  volume={273},
  pages={252 - 255}
}
  • T. Diacovo, K. Puri, +2 authors U. V. von Andrian
  • Published 1996
  • Biology, Medicine
  • Science
  • Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets enhanced tethering of lymphocytes to PNAd and… CONTINUE READING
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