Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules

@article{Diacovo1996PlateletMediatedLD,
  title={Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules},
  author={T. Diacovo and K. Puri and R. Warnock and T. Springer and U. V. von Andrian},
  journal={Science},
  year={1996},
  volume={273},
  pages={252 - 255}
}
Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets enhanced tethering of lymphocytes to PNAd and… Expand
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TLDR
It is reported that P selectin-deficient mice, generated by gene targeting in embryonic stem cells, exhibit a number of defects in leukocytes behavior, including elevated numbers of circulating neutrophils, virtually total absence of leukocyte rolling in mesenteric venules, and delayed recruitment of neutrophil to the peritoneal cavity upon experimentally induced inflammation. Expand
L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways.
TLDR
The results support the concept of a bidirectional interaction between L-selectin bearing sLe(X) on neutrophils and activated EC in vivo, and suggest that L- Selectin may mediate rolling of lymphocytes that lack carbohydrate ligands for E- or P- selectin, although probably less efficiently than through bid Directional recognition. Expand
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TLDR
The model of sequential selectin‐mediated rolling and subsequent integrin‐mediated firm arrest to lymphocytes and ligands expressed on HEV is extended, suggesting that adhesion through PNAd by L‐selectin does not stimulate lymphocyte LFA‐1 avidity for ICAM‐1. Expand
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TLDR
A monoclonal antibody specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV and to be required for lymphocyte homing into lymph nodes in vivo is described. Expand
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TLDR
The mucosal vascular addressin MAdCAM-1, a mucosal endothelial adhesion molecule with immunoglobulin- and mucin-like domains, is a facultative ligand for L-selectin and may be uniquely adapted to support both selectin-mediated lymphocyte rolling and integrin-mediated adhesion and arrest in vivo. Expand
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TLDR
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TLDR
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TLDR
It is demonstrated that PNAd functions as a PLN vascular addressin in humans, and that in addition to directing normal lymphocyte recirculation to lymph nodes and tonsils, this addressin likely participates in lymphocyte recruitment to sites of chronic inflammation. Expand
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TLDR
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TLDR
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