Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum

  title={Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum},
  author={B. McMorran and Laura Wieczorski and K. Drysdale and J. Chan and Hong Ming Huang and Clare Smith and Chalachew Mitiku and J. Beeson and Gaetan Burgio and S. Foote},
  pages={1348 - 1351}
  • B. McMorran, Laura Wieczorski, +7 authors S. Foote
  • Published 2012
  • Biology, Medicine
  • Science
  • Platelets Poison Parasites Activated platelets bound to malaria parasite–infected red blood cells were once thought to contribute to pathogenesis, but recently the platelets have been found to have a protective effect. McMorran et al. (p. 1348; see the Perspective by Engwerda and Good) extended this discovery to show that platelet activation releases intracellular granules containing a chemokine, PF4, which is internalized by Plasmodium falciparum–infected red cells. Subsequently, mature… CONTINUE READING
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