Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation*

@article{Nanda2005PlateletEA,
  title={Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation*},
  author={N. Nanda and M. Bao and Hanna Lin and K. Clauser and L. Komuves and T. Quertermous and P. Conley and D. Phillips and M. Hart},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={24680 - 24689}
}
The present study was designed to identify novel membrane proteins that signal during platelet aggregation. Because one putative mechanism for signaling by a membrane protein involves phosphorylation, we used oligonucleotide-based microarray analyses and mass spectrometric proteomics techniques to specifically discover membrane proteins and also identify those proteins that become phosphorylated on tyrosine, threonine, or serine residues upon platelet aggregation. Surprisingly, both techniques… Expand
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