Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

@inproceedings{Puy2016PlateletDerivedSP,
  title={Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI},
  author={Cristina Puy and Erik Ian Tucker and I. Stefanov Ivanov and David Gailani and Stephanie A. M. Smith and James H Morrissey and Andr{\'a}s Gruber and Owen J T McCarty},
  booktitle={PloS one},
  year={2016}
}
INTRODUCTION Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in vitro. Some of these reactions are now known to be enhanced by short-chain polyphosphates (SCP) derived from activated platelets. These SCPs act as a cofactor for the activation of FXI and FV by thrombin and FXIa, respectively. Since… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

clotting on collagen / tissue factor surfaces under flow

J Duchemin, B Pan-Petesch, B Arnaud, Blouch M-T, Abgrall J-F
  • 2015

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