Platelet-Derived Serotonin Mediates Liver Regeneration

@article{Lesurtel2006PlateletDerivedSM,
  title={Platelet-Derived Serotonin Mediates Liver Regeneration},
  author={Mickael Lesurtel and Rolf Graf and Boris Aleil and Diego J. Walther and Yinghua Tian and Wolfram Jochum and Christian Gachet and Michael Bader and Pierre-Alain Clavien},
  journal={Science},
  year={2006},
  volume={312},
  pages={104 - 107}
}
The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors… 
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Impact of platelets and serotonin on liver regeneration after living donor hepatectomy.
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