Platelet-Derived Serotonin Mediates Liver Regeneration

@article{Lesurtel2006PlateletDerivedSM,
  title={Platelet-Derived Serotonin Mediates Liver Regeneration},
  author={M. Lesurtel and R. Graf and B. Aleil and D. Walther and Y. Tian and W. Jochum and C. Gachet and Michael Bader and Pierre-Alain Clavien},
  journal={Science},
  year={2006},
  volume={312},
  pages={104 - 107}
}
  • M. Lesurtel, R. Graf, +6 authors Pierre-Alain Clavien
  • Published 2006
  • Biology, Medicine
  • Science
  • The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors… CONTINUE READING
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