Platelet-Derived Serotonin Mediates Liver Regeneration

@article{Lesurtel2006PlateletDerivedSM,
  title={Platelet-Derived Serotonin Mediates Liver Regeneration},
  author={Mickael Lesurtel and Rolf Graf and Boris Aleil and Diego J. Walther and Yinghua Tian and Wolfram Jochum and Christian Gachet and Michael Bader and Pierre-Alain Clavien},
  journal={Science},
  year={2006},
  volume={312},
  pages={104 - 107}
}
The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors… 
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The importance of platelet-derived serotonin in mediating hepatic regeneration
Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration.
TLDR
Despite the marked reduction of serotonin levels in blood and platelets, efficient liver regeneration and collagen-induced platelet aggregation occur in rats lacking the serotonin transporter, providing evidence that liver regeneration is not dependent on the release of serotonin from platelets.
Serotonin: a double-edged sword for the liver?
The emerging role of serotonin in liver regeneration.
TLDR
A review article provides a brief overview on the current knowledge about the actions of serotonin in liver regeneration through altered expression of serotonin receptor subtypes in the liver.
Platelet‐derived serotonin: Translational implications for liver regeneration
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This issue of HEPATOLOGY presents the first evidence that plateletderived serotonin plays a critical role in liver regeneration in humans following a hepatectomy and that low preoperative serotonin in platelets is associated with delayed postoperative liver regeneration as well as poorer clinical outcomes.
Can serotonin agonists unlock age-dependent failure of liver regeneration?
  • S. Wigmore
  • Biology, Medicine
    Journal of hepatology
  • 2011
Mechanisms of platelet-mediated liver regeneration.
TLDR
It is widely assumed that platelets stimulate liver regeneration by local excretion of mitogens stored within platelet granules, but definitive evidence for this is lacking and alternative mechanisms deserve consideration.
Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract
TLDR
This study examined the effect of a neural relay on liver regeneration via activation of serotonin release from the gastrointestinal (GI) tract, and demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve fromThe brain, leading to activation of antidepressants from the GI tract and contributing to liver regeneration.
Evidence against a role for platelet-derived molecules in liver regeneration after partial hepatectomy in humans
TLDR
Perioperative changes in platelet and plasma levels of the proteins assessed largely mirror the changes observed in patients undergoing a pylorus-preserving pancreatico-duodenectomy, and the absence of an intra- or postoperative consumption of platelet-derived proteins argues against a role of release of these molecules in stimulation of liver regeneration.
Impact of platelets and serotonin on liver regeneration after living donor hepatectomy.
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