Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

@article{Hayashi2015PlateletDerivedGF,
  title={Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.},
  author={Yujiro Hayashi and Michael R. Bardsley and Yoshitaka Toyomasu and Srdjan Milosavljevic and Gabriella Bedekovicsne Gajdos and Kyoung Moo Choi and Kaye M. Reid-Lombardo and Michael L. Kendrick and Juliane Bingener-Casey and Chih-Min Tang and Jason Sicklick and Simon J. Gibbons and Gianrico Farrugia and T. Taguchi and Anu Gupta and Brian P. Rubin and Jonathan Alfred Fletcher and Abhijit Ramachandran and Tamas Ordog},
  journal={Gastroenterology},
  year={2015},
  volume={149 2},
  pages={420-32.e16}
}
BACKGROUND & AIMS In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is predominantly expressed by interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor-α (PDGFRA) polypeptide is expressed by so-called fibroblast-like cells. KIT and PDGFRA have been reported to be coexpressed in ICC precursors and gastrointestinal stromal tumors (GISTs), which originate from the ICC lineage. PDGFRA signaling has been proposed to stimulate… CONTINUE READING
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