Platelet-Derived Growth Factor-BB Enhances Adipogenesis in Orbital Fibroblasts.

@article{Virakul2015PlateletDerivedGF,
  title={Platelet-Derived Growth Factor-BB Enhances Adipogenesis in Orbital Fibroblasts.},
  author={Sita Virakul and Virgil A. S. H. Dalm and Dion Paridaens and Willem A. van den Bosch and Monique T. Mulder and Nattiya Hirankarn and Petrus Martin van Hagen and Willem A. Dik},
  journal={Investigative ophthalmology \& visual science},
  year={2015},
  volume={56 9},
  pages={
          5457-64
        }
}
  • S. VirakulV. Dalm W. Dik
  • Published 1 August 2015
  • Biology, Medicine
  • Investigative ophthalmology & visual science
PURPOSE Platelet-derived growth factor (PDGF)-BB has been identified as important factor in pathogenesis of Graves' ophthalmopathy (GO). It stimulates proliferation, cytokine, and hyaluronan production, and thyrotropin receptor expression by orbital fibroblasts. Therefore, the PDGF-pathway has been proposed as a target for pharmacological intervention in GO. However, increased adipogenesis is another major pathological characteristic of GO and it is unknown whether this is affected by PDGF-BB… 
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24 Citations
Background Citations
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Results Citations
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24 Citations

Basic Fibroblast Growth Factor Induces Adipogenesis in Orbital Fibroblasts: Implications for the Pathogenesis of Graves' Orbitopathy.

The hypothesis that multi-target directed therapy might be more efficient in the treatment of GO is supported, as the additive effect of bFGF and PDGF-BB on adipogenesis, along with the observed inhibitory effects of dasatinib and nintedanib, point at independent receptor-mediated effects.

Basic FGF and PDGF-BB synergistically stimulate hyaluronan and IL-6 production by orbital fibroblasts

Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1.

Update on pathogenesis and immunology of Graves’ ophthalmopathy

Increased hyaluronic acid production and fibroblast differentiation into adipocytes and myofibroblasts leads to development of graves’ ophthalmopathy, and the elevated number of molecular factors such as PDgF, iL1-β, icaM-1, osteopontin, ctLa-4, and tgF-β are discussed in the paper.

Histone Deacetylase 4 Controls Extracellular Matrix Production in Orbital Fibroblasts from Graves' Ophthalmopathy Patients.

The data indicated for the first time that altered HDAC4 regulation along with H3K9 hypoacetylation might represent a mechanism that contributes to excessive proliferation and extracellular matrix production by orbital fibroblasts in Graves' ophthalmopathy.

Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking.

Hypoxia impacts on tissue remodeling in GO by stimulating angiogenesis and adipogenesis through activation of HIF-1-dependent pathways in OFs and drug-targeted inhibition of Hif-1/VEGF may provide a therapeutic option to control tissue expansion in GO.

Orbital fibroblasts of Graves' orbitopathy stimulated with proinflammatory cytokines promote B cell survival by secreting BAFF

Transgenic PDGF-BB sericin hydrogel potentiates bone regeneration of BMP9-stimulated mesenchymal stem cells through a crosstalk of the Smad-STAT pathways

It is demonstrated that the PDGF-BB sericin hydrogel effectively augmented osteogenesis induced by bone morphogenetic protein (BMP9)-stimulated mesenchymal stem cells (MSCs) in vivo and in vitro, while inhibiting adipogenic differentiation.

Pingmu Decoction Induces Orbital Preadipocytes Apoptosis In Vitro

Pingmu Decoction could reduce orbital preadipocytes viability and induce apoptosis of mature adipocyte via Fas/Fas L signaling pathway and reduce lipid accumulation and downregulated the expression of PPAR γ and C/EBP α.

Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy

Comparisons of proteomics and DNA methylation data support that orbital fibroblasts from active GO are involved in inflammation, adipogenesis, and glycosaminoglycan production, while orbital fibrobasts from inactive disease are more skewed towards an active role in extracellular matrix remodeling.

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  • S. VirakulV. Dalm W. Dik
  • Medicine, Biology
    Graefe's Archive for Clinical and Experimental Ophthalmology
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