Platelet Derived Exosomes Are Enriched for Specific microRNAs Which Regulate WNT Signalling in Endothelial Cells

  title={Platelet Derived Exosomes Are Enriched for Specific microRNAs Which Regulate WNT Signalling in Endothelial Cells},
  author={Eugene Dempsey and Feidhlim Dervin and Patricia B Maguire},
Activated platelets release exosomal vesicles which contain a wide range of proteins and nucleic acids including microRNAs (miRNAs) and crucially these can be delivered to other cells1. The expression of approximately 50% of genes are regulated by miRNAs, therefore, they serve as powerful modulators of signalling networks within cells. In this study, we assess the miRNAs which platelets have the potential to deliver into target cells via secreted exosomes and we particularly focus on how this… 
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