Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype

@article{Podrez2007PlateletCL,
  title={Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype},
  author={Eugene A. Podrez and Tatiana V. Byzova and Maria Febbraio and Robert G Salomon and Yi Ma and Manojkumar Valiyaveettil and Eugenia Poliakov and Mingjiang Sun and Paula J. Finton and Brian R Curtis and Juhua Chen and Renliang Zhang and Roy L Silverstein and Stanley L. Hazen},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={1086-1095}
}
Dyslipidemia is associated with a prothrombotic phenotype; however, the mechanisms responsible for enhanced platelet reactivity remain unclear. Proatherosclerotic lipid abnormalities are associated with both enhanced oxidant stress and the generation of biologically active oxidized lipids, including potential ligands for the scavenger receptor CD36, a major platelet glycoprotein. Using multiple mouse in vivo thrombosis models, we now demonstrate that genetic deletion of Cd36 protects mice from… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 186 CITATIONS, ESTIMATED 49% COVERAGE

Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis.

  • The Journal of clinical investigation
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions.

VIEW 10 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 15 Highly Influenced Citations

  • Averaged 11 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions

Sun, M. et al. Light-induced oxidation of photoreceptor ou epithelium
  • J. Biol. Chem. 281, 4222–4230
  • 2006

Antiinflammatory properties of HDL

Barter, P.J
  • Circ. Res. 95,
  • 2004

Similar Papers

Loading similar papers…