Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype

  title={Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype},
  author={E. Podrez and T. Byzova and M. Febbraio and R. Salomon and Yuliang Ma and M. Valiyaveettil and E. Poliakov and M. Sun and Paula J Finton and B. Curtis and Juhua Chen and R. Zhang and R. Silverstein and S. Hazen},
  journal={Nature Medicine},
  • E. Podrez, T. Byzova, +11 authors S. Hazen
  • Published 2007
  • Medicine
  • Nature Medicine
  • Dyslipidemia is associated with a prothrombotic phenotype; however, the mechanisms responsible for enhanced platelet reactivity remain unclear. Proatherosclerotic lipid abnormalities are associated with both enhanced oxidant stress and the generation of biologically active oxidized lipids, including potential ligands for the scavenger receptor CD36, a major platelet glycoprotein. Using multiple mouse in vivo thrombosis models, we now demonstrate that genetic deletion of Cd36 protects mice from… CONTINUE READING
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