Platelet Activation and Anti-Phospholipid Antibodies Collaborate in the Activation of the Complement System on Platelets in Systemic Lupus Erythematosus

@inproceedings{Lood2014PlateletAA,
  title={Platelet Activation and Anti-Phospholipid Antibodies Collaborate in the Activation of the Complement System on Platelets in Systemic Lupus Erythematosus},
  author={Christian Lood and Helena Tyd{\'e}n and B Gullstrand and Gunnar K Sturfelt and Andreas J{\"o}nsen and Lennart Truedsson and Anders A. Bengtsson},
  booktitle={PloS one},
  year={2014}
}
Anti-phospholipid (aPL) antibodies are important contributors to development of thrombosis in patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE). The underlying mechanism of aPL antibody-mediated thrombosis is not fully understood but existing data suggest that platelets and the complement system are key components. Complement activation on platelets is seen in SLE patients, especially in patients with aPL antibodies, and has been related to venous thrombosis and… CONTINUE READING