Platelet 3H-rauwolscine binding in patients with panic attacks.

  title={Platelet 3H-rauwolscine binding in patients with panic attacks.},
  author={Trevor R. Norman and N M Kimber and Fiona K Judd and Graham Dene Burrows and I M Mcintyre},
  journal={Psychiatry research},
  volume={22 1},
Platelet alpha 2 binding was measured in 14 patients with panic attacks and 21 controls using the antagonist 3H-rauwolscine as radioligand. The mean (+/- SD) Bmax values of patients (116 +/- 45 fmoles/mg protein) and controls (106 +/- 32 fmoles/mg protein) was not significantly different (p greater than 0.05, Mann-Whitney U test). There was a nonsignificant trend for the Kd of patients (1.25 +/- 0.67 nM) to be higher than that of controls (0.96 +/- 0.32 nM). The results do not support an… CONTINUE READING

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