Platelet‐derived growth factor stabilises vascularisation in collagen–glycosaminoglycan scaffolds in vitro

  title={Platelet‐derived growth factor stabilises vascularisation in collagen–glycosaminoglycan scaffolds in vitro},
  author={Ronaldo Jose Farias Correa do Amaral and Brenton L. Cavanagh and Fergal Joseph O'Brien and Cathal J Kearney},
  journal={Journal of Tissue Engineering and Regenerative Medicine},
  pages={261 - 273}
Collagen–glycosaminoglycan (CG) scaffolds have been widely developed for a range of regenerative medicine applications. To enhance their efficacy, CG scaffolds have previously been prevascularised in vitro using human umbilical vein endothelial cells and human mesenchymal stromal cells (hMSCs); however, at later timepoints, a regression of vascularisation is observed. This is undesirable for longer preculture periods (e.g., for partial/full organ regeneration) and for in vitro vascularised… Expand
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